Which antibiotic is recommended for cellulitis secondary to human bite wounds?

Ampicillin/Sulbactam is the recommended antibiotic for cellulitis secondary to human bite wounds due to its broad spectrum of activity against the bacteria typically involved in these types of infections. Human bites can introduce a variety of pathogens, including both aerobic and anaerobic organisms, such as Eikenella corrodens, which is commonly found in human saliva and can cause significant soft tissue infections.

Ampicillin/Sulbactam is a combination of ampicillin, which targets aerobic bacteria, and sulbactam, which inhibits beta-lactamase enzymes produced by some bacteria, enhancing the efficacy of ampicillin against resistant strains. This dual action makes it particularly effective for treating infections stemming from human bites where polymicrobial flora may be present.

In contrast, while other options may cover certain bacteria, they do not provide the same level of coverage for the specific organism profile associated with human bite wounds. For instance, ciprofloxacin has limited activity against anaerobes and is not generally the first choice for this indication. Doxycycline, while effective against some organisms, does not cover Eikenella effectively and may not be sufficient for a mixed infection scenario. Clindamycin is effective against anaerobes and certain gram-positive bacteria but